Many dermal fillers contain hyaluronic acid. HA filler can potentially be broken down using hyaluronidase. This can be useful when filler has produced an unwanted result or in certain filler-related complications. Not every filler can be dissolved, not every unwanted result requires dissolving, and hyaluronidase has its own risks.
Hyaluronidase acts on HA. Products such as Sculptra (PLLA), Radiesse (CaHA) and the CaHA component of HArmonyCa cannot simply be treated as conventional HA-only filler.
Reasons can include lip filler migration, overfilled lips, unwanted facial volume, poor proportions, asymmetry, selected irregularities, a change in aesthetic preference or correction before considering future treatment.
Targeted treatment may be possible, but hyaluronidase should not be marketed as a perfectly precise digital eraser. Sometimes staged correction is more appropriate.
The enzyme begins acting after administration, but the final aesthetic appearance should not necessarily be judged immediately because swelling from the procedure can temporarily alter the area.
Patients may experience swelling, redness, tenderness, bruising or a temporarily uneven appearance. As filler volume reduces, the face or lips may also look substantially different from what the patient has become accustomed to.
Hyaluronidase should not be described as completely harmless. Possible effects include pain, swelling, bruising, redness, temporary aesthetic changes, incomplete correction and hypersensitivity or allergic reactions.
Testing practice depends on the clinical situation, patient history and whether treatment is elective or urgent. An emergency involving suspected HA-filler vascular compromise is different from elective dissolving.
The principle should be correct first, reassess second, refill only if necessary. Immediately adding more filler can make it difficult to understand the final result of dissolving.
Elective dissolving corrects aesthetic concerns such as migration or excess HA filler. Emergency hyaluronidase may be used in urgent management when an HA-filler vascular complication is suspected. These are very different clinical situations.
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